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Biosensor Technology
PANGO® technology of Lemonex is a molecular diagnostic and drug screening technology that can analyze multiple enzymatic activities on
RNA and DNA rapidly and precisely with the utilization of a graphene-biosensor. Viral enzymes such as viral DNA/RNA polymerase and helicase
play important roles in virus replication, infection, and cancer induction. The discovery of inhibitors against these enzymes can be applied to the
development of new virus therapeutics and anti-cancer vaccines. PANGO®, the technology owned by Lemonex, is the next-generation
HTS(High-Throughput Screening) technology that has overcome the disadvantages of pre-existing assay methods. The rapid screening of the
inhibitors of numerous enzymes involved in nucleic acid processing can be used in the development of various antiviral drugs.
Advantages of PANGO®
Emerging Approaches for Graphene Oxide Biosensor. Kim J, Park SJ, Min DH. Anal Chem. 2017; 89(1): 232-248
Biosensors based on Graphene Oxide and Its Biomedical Application. Lee JS, Kim J, Kim S, and Min DH. Adv Drug Deliv Rev.
2016; 105: 275-287.
MicroRNA-Responsive Drug Release System for Selective Fluorescence Imaging and Photodynamic Therapy In Vivo. Lee JS, Kim S,
Na HK, and Min DH. Adv Health Mater. 2016; 5; 2386-2395.
Quantitative and Multiplexed MicroRNA Sensing in Living Cells Based on Peptide Nucleic Acid and Nano Graphene Oxide (PANGO). Ryoo SR,
Lee J, Yeo J, Na HK, Kim YK, Jang H, Lee JH, Han SW, Lee Y, Kim V. Narry, and Min DH. ACS Nano. 2013; 7(7): 5882-5891.
Discovery of Hepatitis C Virus NS3 Helicase Inhibitors by a Multiplexed, High-throughput Helicase Activity Assay Based on Graphene Oxide.
Jang H, Ryoo SR, Kim YK, Yoon S, Kim H, Han SW, Choi BS, Kim DE, and Min DH. Angew Chem Int Ed. 2013; 52(8): 2340-2344.